Symbol
Name
ID

Mmp9
matrix metallopeptidase 9
MGI:97011

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes

Subarachnoid hemorrhage

Bruising susceptibility

Retinal arteritis

Keratoconjunctivitis sicca

Abnormal cardiovascular system morphology

Atrial septal defect

Patent foramen ovale

Secundum atrial septal defect

Ventricular septal defect

Perimembranous ventricular septal defect

Atrioventricular canal defect

Complete atrioventricular canal defect

Double outlet right ventricle

Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis

Tetralogy of Fallot

Bicuspid aortic valve

Ebstein anomaly of the tricuspid valve

Pericarditis

Cardiomegaly

Ascending aortic dissection

Aortic aneurysm

Abdominal aortic aneurysm

Thoracic aortic aneurysm

Aortic root aneurysm

Ascending tubular aorta aneurysm

Descending thoracic aorta aneurysm

Aortic dissection

Descending aortic dissection

Aortic rupture

Mucoid extracellular matrix accumulation

Pulmonary artery stenosis

Partial anomalous pulmonary venous return

Patent ductus arteriosus

Carotid artery dilatation

Carotid artery stenosis

Anterior cerebral artery stenosis

Middle cerebral artery stenosis

Posterior cerebral artery stenosis

Dilatation of the cerebral artery

Moyamoya phenomenon

Coronary artery aneurysm

Coronary artery atherosclerosis

Premature coronary artery atherosclerosis

Coronary artery dissection

Peripheral arterial stenosis

Cystic medial necrosis

Varicose veins

Vasculitis

Stroke

Ischemic stroke

Transient ischemic attack

Abnormal left ventricular function

Aortic regurgitation

Pulmonic stenosis

Hypertension

Cerebral ischemia

Hypovolemia

Arrhythmia

Sudden cardiac death

Myocardial infarction

Abnormality of the lymphatic system

Mediastinal lymphadenopathy

Cutis marmorata

Livedo reticularis

Telangiectasia

Disease(s) Associated with MMP9

coronary artery disease

Down syndrome

Sjogren's syndrome

systemic scleroderma

temporal arteritis

thoracic aortic aneurysm

varicose veins

ventricular septal defect

Mouse Phenotypes

abnormal induced retina neovascularization

abnormal angiogenesis

abnormal physiological neovascularization

increased angiogenesis

thick interventricular septum

increased heart left ventricle posterior wall thickness

cardiac fibrosis

increased susceptibility to dystrophic cardiac calcinosis

decreased susceptibility to induced aneurysm formation

decreased cardiac muscle contractility

increased ventricle muscle contractility

abnormal impulse conducting system conduction

abnormal myocardial fiber physiology

abnormal response to cardiac infarction

decreased myocardial infarct size

enhanced blood-brain barrier function

increased vascular permeability

abnormal vascular smooth muscle physiology

abnormal vascular wound healing

myocarditis

Availability

Mouse Genotype

Mmp9^tm1Amr/Mmp9^tm1Amr

Mmp9^tm1Arnd/Mmp9^tm1Arnd

Mmp9^tm1Tvu/Mmp9^tm1Tvu

Mmp9^tm1Amr/Mmp9⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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